This server contains several tools for short linear motif (SLiM) discovery, peptide characterisation and related analyses of proteomics data.
SLiMs are short (2-12 amino acids) and often redundant, so methods need to allow for chance findings and calculate how likely enrichments are (significance). SLiMs are typically intracellular and often found in unstructured (disordered) protein regions. SLiMs can play roles in protein binding, cleavage, modification and transport (see ELM). Bioactive peptides are typically derived from extracellular proteins.
The tools are hosted by the Shields' Lab, Conway Institute of Biomolecular and Biomedical Research and Complex and Adaptive Systems Laboratory, in University College Dublin. Tools are developed in conjuction with Rich Edward's Lab (University of Southampton) and Norman Davey (UCSF).