SLiMPrints 3.0

SLiMPrints

A motif discovery tool to identify relatively over-constrained proximal groupings of residues within intrinsically disordered regions, indicative of putatively functional motifs. Analysis based on least divergent orthologue alignments created using a database of EnsEMBL metazoan (plus Saccharomyces cerevisiae) genomes (release 59).


Analyse

Find Short, Linear Motif fingerPrints (SLiMPrints). Many take several minutes if the alignment has not been pre-computed.


Example: P04637


Browse

Browse top ranking (Sigmotif < 10-6) predict motifs discovered in the human proteome using the SLiMPrints method here.

Reference

SLiMPrints: conservation-based discovery of functional motif fingerprints in intrinsically disordered protein regions
(In preparation)

Datasets:
Full human analysis (26.9mb zipped) | Human analysis instances (Sigmotif<= 110-3 1.7mb txt)
ELM analysis instances (131kb instance) | ELM analysis protein data (21.9mb txt) | Alignments (12.6mb zipped)


Further Reading

SLiMSearch 2.0: biological context for short linear motifs in proteins.
Davey NE, Haslam NJ, Shields DC, Edwards RJ.
Nucleic Acids Res (July 2011) 39:W56-60.

Masking residues using context-specific evolutionary conservation significantly improves short linear motif discovery.
Davey NE, Shields DC, Edwards RJ.
Bioinformatics (Feb 2009) 15;25(4):443-50.