Hypermethylated in cancer 1 protein (HIC1)
AlignmentMotifsModificationSwitchesStructureMutationIsoformsSNPsFeaturesDisorder

 
|293
|343
|372
MKHE
P
F
Q
K
L
E
E
A
A
P
P
S
D
P
F
R
G
G
S
G
S
P
G
P
E
P
P
G
R
P
D
G
P
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L
L
Y
R
W
M
K
H
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G
L
G
S
Y
G
D
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L
G
R
E
R
G
S
P
S
E
R
C
E
E
R
G
G
D
A
A
V
S
P
G
G
P
P
L
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F
Q
K
L
E
E
A
V
P
P
P
D
P
F
R
G
G
G
G
S
P
G
P
E
P
P
G
R
P
D
G
P
S
L
L
Y
R
W
M
K
H
E
P
G
L
G
S
Y
G
D
E
L
G
R
E
R
G
S
P
S
E
R
C
E
E
R
G
G
D
P
A
A
S
P
G
V
P
P
L
P
F
Q
K
L
E
E
A
V
P
T
P
D
P
F
R
G
S
G
G
S
P
G
P
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P
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R
P
D
G
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L
L
Y
R
W
M
K
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Y
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D
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R
L
E
E
R
G
G
D
P
A
A
S
P
G
G
P
P
L
P
F
Q
K
L
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E
A
G
P
P
P
D
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F
R
G
G
G
G
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D
G
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S
L
L
Y
R
W
M
K
H
E
P
G
L
G
S
Y
G
D
E
L
G
R
E
R
G
S
P
S
E
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C
E
E
R
G
G
D
P
S
A
S
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G
G
P
P
L
P
F
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M
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E
A
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Q
P
L
D
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F
R
-
P
G
G
S
P
G
P
E
P
P
G
R
P
D
G
P
A
L
L
Y
R
W
M
K
A
E
P
G
L
E
P
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
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A
D
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G
D
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P
G
G
P
P
L
P
G
G
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P
G
G
H
P
H
A
T
D
P
F
R
-
-
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T
P
P
C
A
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p
L
P
R
G
D
G
R
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L
M
Y
R
W
M
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H
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-
L
G
P
Y
L
D
E
-
-
-
-
-
-
G
E
A
E
K
E
L
E
R
E
E
K
A
E
S
P
P
A
-
-
-
-
P
Y
Q
R
l
s
E
A
P
T
P
h
e
P
Y
R
N
S
G
P
-
-
-
P
D
H
P
S
R
T
E
T
Q
E
L
M
F
R
W
M
K
H
E
P
-
L
A
S
Y
V
D
E
S
D
R
E
-
-
-
-
-
-
-
-
-
-
-
-
K
D
L
D
R
E
D
K
G
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P
F
P
L
P
N
H
P
L
A
P
N
L
P
H
L
H
R
-
-
S
Q
g
p
p
p
E
P
I
E
D
T
R
D
q
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Y
R
W
V
K
N
E
P
S
N
P
E
D
E
D
E
D
D
E
e
s
G
G
M
G
E
Q
D
K
E
R
H
H
Q
H
M
N
H
H
K
S
N
E
E
M
Y
P
S
m
n
V
S
M
N
M
T
M
H
H
G
Y
G
A
G
D
A
g
s
q
p
P
S
N
S
T
S
A
A
a
v
L
Y
P
P
L
L
S
P
G
H
Y
P
A
S
A
T
Y
S
F
T
-
-
-
-
-
-
-
A
D
F
R
A
P
A
P
T
G
L
G
A
L
P
P
L
 
 
Hypermethylated in cancer 1 protein
Mediates HDAC-dependent transcriptional repression
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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