Hypermethylated in cancer 1 protein (HIC1)
AlignmentMotifsModificationSwitchesStructureMutationIsoformsSNPsFeaturesDisorder

 
|202
|252
|281
GLDLS
E
P
P
S
G
P
E
A
A
V
N
T
H
C
A
E
L
Y
A
S
G
P
G
P
A
A
A
L
C
A
S
E
R
R
C
S
P
L
C
G
L
D
L
S
K
K
S
P
P
G
S
A
A
P
E
R
P
L
A
E
R
E
L
P
P
R
P
D
S
P
P
S
A
G
P
A
A
Y
K
E
E
P
S
S
G
P
E
A
A
V
N
T
H
C
A
E
L
Y
A
S
G
P
G
P
A
S
A
L
C
A
P
E
R
R
C
S
P
L
C
G
L
D
L
S
K
K
S
P
P
G
S
A
P
P
E
R
P
P
G
E
R
D
L
P
S
R
P
D
S
P
P
S
A
G
P
A
A
Y
K
E
E
P
P
S
G
P
D
A
A
V
N
T
H
C
A
E
L
Y
A
S
G
P
G
P
A
A
S
L
C
A
P
E
R
R
C
S
P
L
C
G
L
D
L
S
K
K
S
P
P
G
S
S
V
P
E
R
P
L
S
E
R
E
L
P
P
R
P
D
S
P
P
G
A
G
P
A
V
Y
K
E
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
A
P
E
R
R
C
S
P
L
C
G
L
D
L
S
K
K
S
P
P
G
S
A
-
P
E
R
P
P
G
E
R
E
L
P
P
R
P
D
S
P
P
S
A
G
P
A
A
Y
K
E
E
L
P
P
G
A
E
A
P
V
N
T
H
C
A
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
E
R
R
C
S
P
L
C
G
L
D
L
S
K
K
S
P
P
G
S
a
l
E
R
P
H
P
g
e
R
E
A
P
S
R
H
D
S
S
P
P
-
-
G
A
A
Y
K
E
L
Q
P
V
E
P
A
A
P
L
N
T
Q
C
G
E
L
Y
A
S
A
S
Q
G
T
p
g
L
C
P
P
E
R
H
C
S
P
P
C
G
L
D
L
S
K
K
S
P
T
G
P
S
A
Q
L
L
P
T
d
e
P
S
L
P
P
R
H
D
S
P
P
V
S
g
p
A
A
Y
K
D
L
Q
P
V
E
P
V
N
P
I
N
T
H
C
A
E
L
Y
A
Q
G
N
Q
L
H
q
g
L
C
P
P
E
R
R
C
S
P
L
C
G
L
D
L
S
K
K
S
P
P
R
P
S
A
Q
H
L
S
D
g
e
P
A
V
P
G
R
P
D
S
P
P
V
S
a
s
D
S
Y
K
E
D
L
P
S
I
P
-
-
-
L
P
P
H
A
G
E
I
Y
A
P
A
P
I
K
G
p
p
t
l
P
p
e
R
N
C
S
S
V
Y
G
L
D
L
S
K
K
S
P
N
S
Q
s
s
S
G
N
P
H
l
e
P
E
G
E
L
D
Q
S
T
S
P
M
L
S
P
N
D
G
S
R
F
P
F
S
P
C
G
A
S
Y
N
F
A
A
G
N
P
H
Q
A
A
S
L
S
Y
T
-
-
V
H
p
q
M
L
I
S
P
N
S
H
N
H
G
Q
M
H
S
Q
H
Q
Q
h
q
Q
S
Q
V
Q
a
q
S
S
G
G
N
N
I
G
S
N
G
S
A
g
s
C
Y
Y
E
T
Hypermethylated in cancer 1 protein
Mediates HDAC-dependent transcriptional repression
Interaction with CTBP1
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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