Histone-lysine N-methyltransferase MLL (MLL)
AlignmentMotifsModificationSwitchesStructureMutationIsoformsSNPsFeaturesDisorder

 
|2677
|2727
|2756
QLDGVDD
D
D
L
Y
Y
Y
N
F
T
R
T
V
I
S
S
G
G
E
E
R
L
A
S
H
N
L
F
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E
E
E
Q
C
D
L
P
K
I
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L
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D
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N
G
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N
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L
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D
D
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Y
Y
Y
N
F
T
R
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V
I
S
S
G
G
E
E
R
L
A
S
H
N
L
F
R
E
E
E
Q
C
D
L
P
K
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L
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G
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D
D
G
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K
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S
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I
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K
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N
G
K
E
N
G
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N
L
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D
D
D
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Y
Y
Y
N
F
T
R
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I
S
S
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G
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E
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L
A
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H
N
L
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E
E
Q
C
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D
D
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T
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K
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S
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K
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N
G
K
E
N
G
T
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N
L
K
I
D
D
D
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Y
Y
Y
N
F
T
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T
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S
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G
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E
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N
L
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E
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Q
C
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L
P
K
I
S
Q
L
D
G
V
D
D
G
T
E
S
D
T
S
V
T
A
T
S
R
K
S
S
Q
I
P
K
R
N
G
K
E
N
G
T
E
N
L
K
I
D
D
D
L
Y
Y
Y
N
F
S
R
T
V
I
S
S
G
G
E
E
R
L
T
P
H
N
L
F
R
E
E
E
Q
C
D
L
P
K
I
S
Q
L
D
G
I
D
D
G
T
E
S
D
T
S
V
T
A
T
T
R
K
S
S
Q
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K
R
N
S
K
E
N
G
T
E
N
L
K
M
D
D
D
L
Y
Y
Y
N
F
T
R
T
V
I
S
S
S
G
E
E
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L
G
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N
L
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L
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K
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V
S
Q
L
P
K
R
N
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K
E
N
G
T
E
N
L
K
L
D
D
D
L
Y
Y
Y
N
F
T
R
T
V
V
S
S
N
T
E
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L
A
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L
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D
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Y
Y
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N
F
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G
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A
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C
N
T
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T
V
-
-
T
K
S
S
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G
K
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K
L
Q
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Y
Y
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T
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T
I
I
N
p
g
I
D
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L
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t
t
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k
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T
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T
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N
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G
Q
N
L
L
Q
P
Q
L
L
F
Q
S
S
T
Q
T
Q
A
P
Q
I
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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I
L
P
-
-
Q
A
Q
P
Q
-
-
-
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-
-
-
-
-
-
-
-
n
i
S
F
V
-
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-
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-
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F
L
R
P
I
L
S
D
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
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-
-
-
-
-
-
-
-
-
A
T
P
K
T
L
P
L
T
L
I
P
Q
N
-
-
-
-
-
-
-
-
-
-
-
-
-
 
 
 
 
Histone-lysine N-methyltransferase MLL
MLL cleavage product N320
MLL cleavage product C180
Cleavage; by TASP1, site 2
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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