Transcription factor Sp3 (SP3)
AlignmentMotifsModificationSwitchesStructureMutationIsoformsSNPsFeaturesDisorder

 
|511
|561
|590
IKEE
V
S
L
S
T
G
Q
L
P
N
L
Q
T
V
T
V
N
S
I
D
S
A
G
I
Q
L
H
P
G
E
N
A
D
S
P
A
D
I
R
I
K
E
E
E
P
D
P
E
E
W
Q
L
S
G
D
S
T
L
N
T
N
D
L
T
H
L
R
V
Q
V
V
D
E
E
G
D
Q
Q
H
Q
V
S
L
S
T
G
Q
L
P
N
L
Q
T
V
T
V
N
S
I
D
S
T
G
I
Q
L
H
P
G
E
N
A
D
S
P
A
D
I
R
I
K
E
E
E
P
D
P
E
E
W
Q
L
S
G
D
S
T
L
N
T
N
D
L
T
H
L
R
V
Q
V
V
D
E
E
G
D
Q
Q
H
Q
V
S
L
S
T
G
Q
L
P
N
L
Q
T
V
T
V
N
S
I
D
S
T
G
I
Q
L
H
P
G
E
N
A
D
S
P
A
D
I
R
I
K
E
E
E
P
D
P
E
D
W
Q
L
S
G
D
S
T
L
N
T
N
D
L
T
H
L
R
V
Q
V
V
D
E
E
G
D
Q
P
H
Q
V
S
L
S
T
G
Q
L
P
N
L
Q
T
V
T
V
N
S
I
D
S
T
G
I
Q
L
H
S
G
E
N
A
D
S
P
A
D
I
R
I
K
E
E
E
P
D
P
E
E
W
Q
L
S
G
D
S
T
L
N
T
S
D
L
T
H
L
R
V
Q
V
V
D
E
E
G
D
Q
P
H
Q
V
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L
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N
L
Q
T
V
T
V
N
S
I
D
S
A
G
I
Q
L
H
P
G
E
N
A
D
S
P
A
D
I
R
I
K
E
E
E
P
D
P
E
E
W
Q
L
S
G
D
S
T
L
N
T
N
D
L
T
H
L
R
V
Q
V
V
D
E
E
G
D
Q
Q
H
Q
V
S
L
S
T
A
Q
L
P
N
L
Q
T
V
T
V
N
S
I
D
S
A
G
I
Q
L
H
Q
G
E
N
A
G
S
P
A
D
I
R
I
K
E
E
E
P
D
P
E
E
W
Q
L
S
G
D
S
T
L
N
T
N
D
L
T
H
L
R
V
Q
V
V
D
E
E
G
D
Q
P
H
Q
V
S
L
S
T
G
Q
L
P
N
L
Q
T
V
T
V
N
S
I
D
S
T
G
I
Q
L
H
P
G
E
N
A
D
S
P
A
D
I
R
I
K
E
E
E
P
D
P
E
E
W
Q
L
S
G
D
S
T
L
N
T
N
D
L
T
H
L
R
V
Q
V
V
D
E
E
G
D
Q
Q
H
Q
V
S
L
N
A
G
Q
L
P
N
L
Q
T
V
T
V
N
S
V
D
A
A
G
I
H
L
H
H
G
D
N
S
D
S
P
T
G
I
R
I
K
E
E
E
P
D
P
D
E
W
Q
L
A
G
D
S
T
V
N
T
N
D
L
T
H
L
R
V
Q
V
V
D
D
E
L
D
Q
P
N
Q
V
S
L
S
S
G
Q
M
P
N
L
Q
S
V
T
V
N
T
V
G
Q
A
G
I
Q
F
Q
Q
S
E
D
T
D
S
T
G
D
I
Q
I
K
E
E
-
P
D
S
E
E
W
P
L
D
S
S
S
T
L
N
A
N
D
L
S
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L
R
V
R
L
V
E
E
E
M
E
A
L
S
Q
V
Q
N
I
P
G
-
L
G
N
V
Q
V
I
P
A
S
A
L
Q
P
A
T
V
Q
T
L
P
A
T
A
-
A
T
p
a
A
P
T
V
Q
L
D
S
N
D
P
T
K
W
Q
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q
S
N
N
T
L
A
T
P
T
P
T
S
H
Q
H
Q
v
i
E
T
D
S
N
K
Q
H
R
v
R
L
T
T
A
N
g
p
G
A
A
G
I
S
L
A
R
V
-
-
-
-
I
Q
M
Q
N
N
G
N
A
N
V
a
l
S
A
A
A
N
S
G
S
S
N
S
N
S
N
S
S
S
S
N
T
S
S
N
S
I
N
T
A
T
P
Q
Q
Q
V
L
S
Q
R
S
E
K
S
-
A
V
A
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
G
P
S
A
P
A
R
K
P
N
Q
I
Q
H
R
Q
M
I
P
-
-
-
-
-
Q
M
N
E
D
G
M
M
N
M
-
-
-
-
-
-
-
-
-
-
G
N
D
Y
G
D
I
N
G
q
S
V
V
I
T
G
K
V
N
N
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
N
N
V
V
D
S
T
L
K
E
-
-
-
-
-
-
-
-
-
-
T
V
S
S
A
-
-
-
-
-
V
S
S
M
G
L
L
Q
V
Q
D
E
T
S
T
Q
P
T
 
 
 
Transcription factor Sp3
Repressor domain
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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