Amyloid beta A4 protein (APP)
AlignmentMotifsModificationSwitchesStructureMutationIsoformsSNPsFeaturesDisorder

 
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|768
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Basolateral sorting signal
NPXY motif; contains endocytosis signal
 
 
 
 
 
 
In isoform APP305.
F
G
I
L
P
Amyloid beta A4 protein
C99
C83
C80
Gamma-secretase C-terminal fragment 59
Gamma-secretase C-terminal fragment 57
Gamma-secretase C-terminal fragment 50
C31
Helical;
Cytoplasmic
Interaction with G(o)-alpha
Cleavage; by gamma-secretase; site 3
Cleavage; by caspase-6, caspase-8 or caspase-9
In Ref. 22; AAB26263/AAB26264.
In Ref. 22; AAB26263/AAB26264/AAB26265.
In Ref. 30; AAA35540.
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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