Vitamin K-dependent protein C (PROC)
AlignmentMotifsModificationSwitchesStructureMutationIsoformsSNPsFeaturesDisorder

 
|332
|382
|411
NEC
Q
A
G
Q
E
T
L
V
T
G
W
G
Y
H
S
S
R
E
K
E
A
K
R
N
R
T
F
V
L
N
F
I
K
I
P
V
V
P
H
N
E
C
S
E
V
M
S
N
M
V
S
E
N
M
L
C
A
G
I
L
G
D
R
Q
D
A
C
E
G
D
S
G
G
P
M
V
A
S
F
H
Q
A
G
Q
E
T
L
V
T
G
W
G
Y
H
S
S
R
E
K
E
A
K
R
N
R
T
F
V
L
N
F
I
K
I
P
V
V
P
H
N
E
C
S
E
V
M
S
N
M
V
S
E
N
M
L
C
A
G
I
L
G
D
R
Q
D
A
C
E
G
D
S
G
G
P
M
V
A
S
F
H
Q
A
G
Q
E
T
L
V
T
G
W
G
Y
H
S
S
R
E
K
E
A
K
R
N
R
T
F
V
L
N
F
I
K
I
P
V
V
P
H
N
E
C
S
E
V
M
S
N
M
V
S
E
N
M
L
C
A
G
I
L
G
D
R
Q
D
A
C
E
G
D
S
G
G
P
M
V
A
S
F
H
Q
A
G
Q
E
T
V
V
T
G
W
G
Y
Q
S
D
R
I
K
D
G
R
R
N
R
T
F
I
L
T
F
I
R
I
P
L
V
A
R
N
E
C
V
E
V
M
K
N
V
V
S
E
N
M
L
C
A
G
I
I
G
D
T
R
D
A
C
D
G
D
S
G
G
P
M
V
V
F
F
R
Q
V
G
Q
E
T
V
V
T
G
W
G
Y
R
D
-
-
-
-
E
T
K
R
N
R
T
F
V
L
S
F
I
K
V
P
V
V
P
Y
N
A
C
V
H
A
M
E
N
K
I
S
E
N
M
L
C
A
G
I
L
G
D
P
R
D
A
C
E
G
D
S
G
G
P
M
V
T
F
F
R
K
V
G
R
E
M
V
I
T
G
W
G
R
Q
R
-
-
-
-
E
E
S
R
N
R
T
Y
V
L
R
F
T
K
I
P
L
A
S
H
D
E
C
S
Q
T
M
H
N
R
V
S
E
N
M
L
C
A
G
I
L
R
D
K
R
D
A
C
E
G
D
S
G
G
P
M
V
T
E
F
R
T
K
G
R
Q
M
L
V
T
G
W
G
S
T
S
-
-
-
-
D
E
M
R
N
Y
S
A
L
L
S
Y
I
E
I
P
I
V
P
K
N
E
C
A
Q
V
M
T
N
T
I
S
D
N
M
L
C
A
G
S
L
G
D
R
K
D
S
C
S
G
D
S
G
G
P
M
A
T
K
Y
K
M
D
D
T
V
V
A
V
T
G
W
G
R
E
D
-
-
-
-
E
T
A
L
N
Y
S
S
V
L
S
Y
I
Q
I
P
I
A
P
R
N
Q
C
A
E
T
L
K
D
G
V
S
D
N
M
L
C
A
G
Q
L
G
H
I
Q
D
A
C
Y
G
D
S
G
G
P
M
V
T
K
F
G
R
N
G
T
V
T
V
I
T
G
W
G
K
N
N
-
-
-
-
Q
S
A
T
S
Y
N
S
T
L
H
Y
V
E
L
P
I
V
D
N
K
E
C
S
R
H
M
M
N
N
L
S
D
N
M
L
C
A
G
V
L
G
Q
V
K
D
A
C
E
G
D
S
G
G
P
M
M
T
L
F
H
P
P
G
A
R
C
W
V
T
G
Y
G
T
T
A
Y
R
G
P
A
A
K
-
-
-
-
-
I
L
R
E
V
Q
L
P
I
V
D
I
N
T
C
A
-
R
S
Y
n
i
D
T
Q
K
M
L
C
A
G
Y
R
G
G
G
R
D
A
C
Q
G
D
S
G
G
P
L
V
C
Q
R
C
S
M
D
D
A
L
I
T
R
W
N
V
Vitamin K-dependent protein C
Vitamin K-dependent protein C heavy chain
Peptidase S1
Charge relay system
N-linked (GlcNAc...)
N-linked (GlcNAc...); partial; atypical
disulfide bond
disulfide bond
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

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